It has not yet been confirmed what the nature of the incident is.
Devon and Cornwall Police Force Incident Manager, have confirmed there is an operation taking place on Ham Drive.
The local police force is expected to provide more details in due course.
Local residents have claimed they have been asked to remain in their homes.
In pictures from Plymouth Live, police dogs have also arrived at the scene.
A journalist for the paper, Erin Black has also reported seeing firefighters and paramedics descended on the scene near the Cherry Tree pub.
Local bus services have now been suspended until the incident is dealt with.
Plymouth: Major police incident declared
Plymouth: FIre crews have arrived at the scene
Plymouth Citybus said: “Due to major police incident closing off Ham Drive near Cherry Tree.
“Services PCB35, PCB35A, PCB35B are on diversion, from Merrivale Rd normal route to Recreaction Rd, Beacon Park Rd, onto North Prospect Rd, left Seagrave Rd, left onto Outland Rd then right at Peverell Pk Rd.”
There has no confirmation if there any injuries from the incident.
The incident in Plymouth comes as the Metropolitan Police clashed with members of the public on Friday night.
Plymouth: Armed police are also present
Riot police were called to an illegal gathering in White City, west London.
After confronting the revellers, police were pelted with bottles and missiles.
This mark the latest in a string of clashes between the police and groups across the capital.
Following the incident, the Met Police said: “Seven police officers injured and police vehicles damaged during response to an unlicensed music event in White City area of London.”
More to follow…